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In some cases, doctors can use pharmacogenomic knowledge as one of the tools for practicing precision medicine. By knowing how someone's genes might affect how the body will handle or respond to a particular drug, a health care provider might change the type or amount of medicine given. This may lead to a better health outcome or make dangerous side effects less likely.

Differences in someone's genes or "pharmacogenome" can affect how the person responds to a drug in a number of ways:. Use of pharmacogenomic information to select a drug or dose of drug in the clinical setting is progressing rapidly and is available mostly in large metropolitan medical centers. This requires testing a tumor sample. These changes influence how effective and safe a drug is for a person. For example, a person's body may process a medicine more quickly than others. This means the person would require a higher dose for the drug to be effective.

The drug would then stay in the bloodstream longer.

A Conversation With Howard L. McLeod, PharmD

And this may cause more severe side effects. People with colorectal cancer sometimes have a specific altered gene. These people may have serious side effects when treated with the drug irinotecan Camptosar. The altered gene makes it harder for the body to break down the drug.

Doctors prescribe lower doses of the medicine for these people to reduce side effects. Personalized medicine for cancer treatment is still under development. Researchers want to learn more about:. Talk with your health care team to find out if your treatment plan will include personalized medicine.

Request Permissions. What Is Personalized Cancer Medicine? Approved by the Cancer. Creating a personalized cancer screening and treatment plan involves: Identifying the chances of a person developing cancer and selecting screening strategies to lower the risk Matching people with treatments that may be more effective and cause fewer side effects Predicting the risk of recurrence, which is the return of cancer How personalized medicine is different Before personalized medicine, most people with a specific type and stage of cancer received the same treatment.

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Pharmacogenetics: Making cancer treatment safer and more effective

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Pharmacogenetics: Making cancer treatment safer and more effective - Google книги

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Breast Cancer Treatment Decision Making - Mayo Clinic

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